Description

4-(1,4-Dioxaspiro[4.5]dec-8-yl)benzonitrile is a versatile and high-value organic intermediate featuring a benzonitrile moiety attached to a spirocyclic ketal-protected cyclohexanone system. This unique molecular architecture makes it a critical building block for the synthesis of complex molecules, particularly in advanced pharmaceutical research and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that require complex, functionalized cyclic structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the research of advanced polymers and liquid crystals where the rigid, functionalized spirocyclic unit can impart specific physical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	4-(1,4-Dioxaspiro[4.5]dec-8-yl)benzonitrile
CAS No.	149507-27-7
Molecular Formula	C₁₇H₁₉NO₂
Molecular Weight	269.34 g/mol
Synonyms	4-(1,4-Dioxaspiro[4.5]dec-8-yl)benzonitrile; 4-(1,4-Dioxaspiro[4.5]decan-8-yl)benzonitrile; 4-(8-Cyano-1,4-dioxaspiro[4.5]dec-8-yl)benzonitrile; 4-(1,4-Dioxaspiro[4.5]dec-8-yl)benzenecarbonitrile; Benzonitrile, 4-(1,4-dioxaspiro[4.5]dec-8-yl)-; 149507-27-7; 4-(1,4-Dioxaspiro[4,5]dec-8-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-(1,4-Dioxaspiro[4.5]dec-8-yl)benzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for identity confirmation. A Certificate of Analysis (COA) detailing all specifications is supplied with each batch to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.