Description

Jaspisamide A is a naturally occurring cyclic depsipeptide isolated from marine sponges of the genus *Jaspis*, recognized for its potent cytotoxic and antiproliferative activity against multiple human cancer cell lines. This high-purity research-grade compound serves as a critical molecular probe in oncology drug discovery, enabling structure–activity relationship (SAR) studies and target validation efforts. It is primarily utilized by pharmaceutical R&D laboratories, academic biomedical research centers, and contract research organizations (CROs) engaged in anticancer natural product development. Jaspisamide A CAS NO 149420-76-8 is supplied under stringent quality controls to ensure batch-to-batch consistency and biological reproducibility.

Application

• Oncology drug discovery: Lead compound screening for tubulin polymerization inhibition and apoptosis induction
• Mechanistic pharmacology studies: Investigation of mitochondrial membrane potential disruption and caspase activation pathways
• Chemical biology tool: Selective labeling and pull-down assays for identifying novel protein targets
• Marine natural product library expansion for high-throughput phenotypic screening platforms
• Synthesis benchmark: Challenging target for total synthesis and analog generation (e.g., C-terminus modified derivatives)
• Reference standard for LC-MS/MS quantification in pharmacokinetic and biodistribution studies
• Antitumor mechanism validation in xenograft and PDX mouse models
• Combination therapy research with checkpoint inhibitors and DNA-damaging agents

Basic Information

Product Name	Jaspisamide A
CAS No.	149420-76-8
Molecular Formula	C53H79N9O13
Molecular Weight	1078.25 g/mol
Synonyms	Jaspamide A; Jaspamide; Jasplakinolide analog A; Cyclo-(D-Val-L-Leu-D-Val-L-Ile-L-Val-D-Val-L-Leu-D-Val-L-Ile); Depsipeptide Jaspisamide A; Jaspisamide-A; Jaspamide A (Jaspamide A1); Jaspamide derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of Jaspisamide A is verified for identity (HPLC retention time match, HRMS), purity (≥98.5% by HPLC-UV at 220 nm), and absence of microbial contamination. Testing adheres to ICH Q5, Q7, and ISO 9001:2015 guidelines. For research-grade material, specifications meet or exceed ACS Reagent Grade requirements for organic reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at –20 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Avoid repeated freeze-thaw cycles. Keep desiccated; moisture-sensitive compounds should be handled in a controlled humidity environment (<30% RH).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (HRMS)	[M+H]+ m/z 1079.2562 ± 0.005 (calcd. for C53H80N9O13)
Assay (HPLC-UV)	≥98.5%
Related Substances	Single impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents	MeOH ≤3000 ppm; Acetonitrile ≤410 ppm; DCM ≤600 ppm
Water Content (KF)	≤5.0%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.