Description

De-4'-o-Methylyangambin is a specialized lignan compound of significant interest in advanced chemical research and development. Its unique structural framework makes it a valuable intermediate for synthesizing novel bioactive molecules and a critical reference standard for analytical studies. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, nutraceutical, and fine chemical sectors who require reliable, well-characterized building blocks for drug discovery and quality control protocols.

Application

• Pharmaceutical Research Intermediate: Serves as a key synthetic precursor or scaffold in the development of new therapeutic agents, particularly those targeting inflammation or metabolic pathways.
• Analytical Reference Standard: Used in High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) for the identification, quantification, and purity assessment of yangambin derivatives in complex matrices.
• Bioactivity Studies: Employed in in vitro and in vivo research to investigate the pharmacological properties of modified lignans, such as antioxidant, anti-inflammatory, or enzyme inhibitory effects.
• Natural Product Chemistry: Acts as a derivative for comparative studies in the isolation, characterization, and structure-activity relationship (SAR) analysis of natural lignans from plant sources.
• Fine Chemical Synthesis: Utilized as a high-value building block for the custom synthesis of complex organic molecules in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	De-4'-o-Methylyangambin
CAS No.	149250-48-6
Molecular Formula	C23H26O8
Molecular Weight	430.45 g/mol
Synonyms	4'-O-Demethyl-yangambin; Desmethyl-yangambin; Yangambin, 4'-O-desmethyl-; (7S,8R,7'S,8'R)-4,4'-Dihydroxy-3,3',5,5'-tetramethoxy-7,7'-epoxylignan; Lignan F10; A derivative of yangambin.
EINECS	Contact for details

Quality Control

Our De-4'-o-Methylyangambin is produced under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot is thoroughly characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.