Description

m-(Trimethylsilyldifluoromethyl)-Trifluoromethylbenzene is a highly fluorinated and silylated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique combination of fluorine and silicon functionalities, which impart exceptional properties like enhanced lipophilicity, metabolic stability, and electronic effects to target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating novel active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the (trimethylsilyl)difluoromethyl and trifluoromethyl groups into drug candidates, particularly in medicinal chemistry for probing structure-activity relationships and improving bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic display materials, contributing to improved thermal stability, dielectric anisotropy, and luminescent properties.
• Polymer & Resin Modification: Incorporated into specialty polymers to alter surface energy, increase chemical resistance, and modify optical characteristics for advanced coatings and films.
• Fluorine Chemistry Research: An essential reagent for studying novel fluorination methodologies and the development of new organofluorine compounds in academic and industrial laboratories.
• Lithography & Semiconductor Materials: Potential use in the formulation of photoresists and etching agents for microelectronics fabrication due to its silicon and fluorine content.

Basic Information

Product Name	m-(Trimethylsilyldifluoromethyl)-Trifluoromethylbenzene
CAS No.	149194-34-3
Molecular Formula	C11H13F5Si
Molecular Weight	268.30 g/mol
Synonyms	1-[(Trimethylsilyl)difluoromethyl]-3-(trifluoromethyl)benzene; 3-((Trimethylsilyl)difluoromethyl)-α,α,α-trifluorotoluene; m-(Trimethylsilyl)difluoromethyl-α,α,α-trifluorotoluene; Benzene, 1-[(trimethylsilyl)difluoromethyl]-3-(trifluoromethyl)-; (3-(Trifluoromethyl)phenyl)(trimethylsilyl)difluoromethane; TMS-CF2-C6H4-CF3 (meta isomer)
EINECS	Contact for details

Quality Control

Our m-(Trimethylsilyldifluoromethyl)-Trifluoromethylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.