Description

tert-Butyl 3-Amino-3-Phenylpropanoate is a versatile chiral β-amino acid ester derivative, serving as a crucial building block in organic synthesis. Its value lies in providing a protected amine and carboxylic acid functionality, enabling efficient construction of complex molecules. This intermediate is primarily needed by the pharmaceutical industry for the development of active pharmaceutical ingredients (APIs) and by research institutions for medicinal chemistry and peptide synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Peptidomimetics: Used in the design and synthesis of peptide analogs with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or chiral auxiliary in catalytic asymmetric reactions to introduce stereocenters.
• Agrochemical Research: Serves as a precursor for developing novel, biologically active compounds in crop protection.
• Fine Chemical Production: Integral in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic & R&D: Utilized in research laboratories for methodological development and exploring new synthetic pathways.

Basic Information

Product Name	tert-Butyl 3-Amino-3-Phenylpropanoate
CAS No.	149193-92-0
Molecular Formula	C₁₃H₁₉NO₂
Molecular Weight	221.30 g/mol
Synonyms	3-Amino-3-phenylpropanoic acid tert-butyl ester; tert-Butyl β-amino-β-phenylpropionate; (R/S)-tert-Butyl 3-amino-3-phenylpropanoate; 3-Phenyl-β-alanine tert-butyl ester; β-Amino-β-phenylpropionic acid tert-butyl ester; BOC-Phe-β-Ala-OH tert-butyl ester precursor; (3-Amino-3-phenyl-propanoyloxy)-tert-butane
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Amino-3-Phenylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.