Description

tert-Butyl 5-{[(Trifluoromethyl)Sulfonyl]Oxy}-3,4-Dihydropyridine-1(2H)-Carboxylate (Saltdata: Free) is a high-value, protected intermediate featuring a reactive triflate leaving group. This compound matters as a critical building block in modern organic synthesis, enabling efficient carbon-carbon and carbon-heteroatom bond formation under mild conditions. Pharmaceutical and agrochemical R&D teams need it for constructing complex nitrogen-containing heterocycles, which are core scaffolds in many active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of piperidine and dihydropyridine-based active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) for introducing functionalized pyridine motifs.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with heterocyclic structures.
• Material Science Research: Used in the development of organic ligands, catalysts, and advanced functional materials.
• Nucleophilic Substitution: The activated sulfonate ester group is readily displaced by a wide range of nucleophiles, facilitating diverse molecular diversification.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group allows for orthogonal protection/deprotection sequences in multi-step synthetic routes.

Basic Information

Product Name	tert-Butyl 5-{[(Trifluoromethyl)Sulfonyl]Oxy}-3,4-Dihydropyridine-1(2H)-Carboxylate (Saltdata: Free)
CAS No.	149108-74-7
Molecular Formula	C11H16F3NO5S
Molecular Weight	331.31 g/mol
Synonyms	1-Boc-5-(trifluoromethanesulfonyloxy)-1,2,3,4-tetrahydropyridine; tert-Butyl 5-((trifluoromethyl)sulfonyloxy)-3,4-dihydro-2H-pyridine-1-carboxylate; 1,2,3,4-Tetrahydro-5-[[(trifluoromethyl)sulfonyl]oxy]-1-pyridinecarboxylic acid 1,1-dimethylethyl ester; 5-(Triflyloxy)-1,2,3,4-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1-Boc-5-OTf-1,2,3,4-tetrahydropyridine; N-Boc-5-triflyloxy-1,2,3,4-tetrahydropyridine; 1-(tert-Butoxycarbonyl)-5-(trifluoromethanesulfonyloxy)-1,2,3,4-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-{[(Trifluoromethyl)Sulfonyl]Oxy}-3,4-Dihydropyridine-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.