Description

(Trimethylsilyldifluoromethyl)Benzene is a specialized organosilicon reagent featuring a reactive difluoromethyl group. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly for introducing fluorinated moieties. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, leveraging the difluoromethyl group to modulate metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where fluorine substitution enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the production of specialty polymers and advanced materials with tailored surface properties.
• Fluorination Reagent: Acts as a source of the -CF2H group in nucleophilic or radical fluorination reactions under various catalytic conditions.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel silicon-containing ligands for catalysis.
• Organic Electronics: Investigated as a building block for charge-transport materials or emissive layers in OLEDs and other electronic devices.

Basic Information

Product Name	(Trimethylsilyldifluoromethyl)Benzene
CAS No.	149021-01-2
Molecular Formula	C10H14F2Si
Molecular Weight	200.30 g/mol
Synonyms	Benzene, [(difluoromethyl)trimethylsilyl]-; [(Difluoromethyl)trimethylsilyl]benzene; α,α-Difluoro-α-(trimethylsilyl)toluene; (Difluoromethyl)trimethylphenylsilane; Trimethyl(difluoromethylphenyl)silane; TMS-CF2-Ph; (Trimethylsilyl)difluoromethylbenzene
EINECS	Contact for details

Quality Control

Our production of (Trimethylsilyldifluoromethyl)Benzene adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed via GC, NMR, and other appropriate spectroscopic methods to confirm identity and assess impurity profiles. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.