Description

4-Fluorobenzylisocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative of 4-fluorotoluene. Its primary value lies in its role as a critical reactant in multi-component coupling reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and pharmacophores. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to construct novel molecular entities for drug discovery and specialty chemical applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for constructing imidazole, oxazole, and other nitrogen-containing heterocycles via Ugi, Passerini, and related multi-component reactions.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides by introducing the isocyanide functional group into target molecules.
• Ligand Synthesis for Catalysis: Used to prepare specialized isocyanide-based ligands for transition metal catalysts used in fine chemical synthesis.
• Material Science: Serves as a building block for functional polymers and smart materials that incorporate the isocyanide moiety for specific electronic or binding properties.
• Chemical Biology & Probe Development: Utilized in bio-conjugation strategies and for creating chemical probes to study biological processes.

Basic Information

Product Name	4-Fluorobenzylisocyanide
CAS No.	148890-53-3
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	1-Isocyano-4-(fluoromethyl)benzene; (4-Fluorophenyl)methyl isocyanide; p-Fluorobenzyl isocyanide; 4-Fluorobenzyl isonitrile; 4-Fluorobenzyl Isocyanide; 4-Fluorobenzyl Isonitrile; (4-Fluorobenzyl)isocyanide; α-Isocyano-4-fluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 4-Fluorobenzylisocyanide is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity organic intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.