Description

(2,5-Dioxopyrrolidin-1-Yl) 2-Oxochromene-3-Carboxylate is a specialized heterocyclic building block and active ester intermediate of significant interest in advanced organic synthesis. Its core value lies in its reactivity as a coupling agent, facilitating the efficient formation of amide bonds under mild conditions, which is critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in creating amide-linked active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as an activating agent for carboxylic acids in solid-phase and solution-phase peptide coupling reactions.
• Bioconjugation: Facilitates the labeling and cross-linking of biomolecules (proteins, antibodies) for diagnostic and therapeutic applications.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialized polyamides and functional polymeric materials.
• Agrochemical Research: Intermediate in the design and synthesis of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Enables the synthesis of activity-based probes for studying enzyme function and metabolic pathways.

Basic Information

Product Name	(2,5-Dioxopyrrolidin-1-Yl) 2-Oxochromene-3-Carboxylate
CAS No.	148627-84-3
Molecular Formula	C14H9NO6
Molecular Weight	287.23 g/mol
Synonyms	3-Coumarincarboxylic acid N-hydroxysuccinimide ester; 2-Oxo-2H-chromene-3-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester; 2-Oxo-2H-1-benzopyran-3-carboxylic acid 2,5-dioxo-1-pyrrolidinyl ester; NSC 332008; NHS ester of 3-carboxycoumarin; 3-Carboxycoumarin N-succinimidyl ester; Coumarin-3-carboxylic acid N-succinimidyl ester; 1-[(2-Oxo-2H-chromen-3-yl)carbonyloxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our (2,5-Dioxopyrrolidin-1-Yl) 2-Oxochromene-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.