Description

4-Fluoro-1-Isocyanato-2-Methoxybenzene (Wx681004) is a versatile aromatic isocyanate building block, specifically functionalized with fluorine and methoxy groups. This compound is critical for introducing the isocyanate moiety into complex molecular architectures, enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the production of novel herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for synthesizing specialty polyurethanes and polymers with tailored thermal or surface properties.
• Liquid Crystal & OLED Materials: Acts as a precursor for electron-transport or emissive layer materials in display technologies.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes (ABPs) and other research tools for studying enzyme function.
• Custom Synthesis & Contract Manufacturing: An essential building block for custom synthesis projects and scale-up campaigns in fine chemical production.

Basic Information

Product Name	4-Fluoro-1-Isocyanato-2-Methoxybenzene (Wx681004)
CAS No.	148624-87-7
Molecular Formula	C8H6FNO2
Molecular Weight	167.14 g/mol
Synonyms	2-Methoxy-4-fluorophenyl isocyanate; 4-Fluoro-2-methoxyphenyl isocyanate; 1-Isocyanato-4-fluoro-2-methoxybenzene; 2-Methoxy-4-fluoro-1-isocyanatobenzene; 4-Fluoro-o-anisyl isocyanate; WX-681004; (4-Fluoro-2-methoxyphenyl) isocyanate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-1-Isocyanato-2-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.