Description

Methyl 5-Fluoro-4-Methylpicolinate CAS NO 148541-72-4 is a high-purity fluorinated picolinate ester, a crucial building block in modern synthetic chemistry. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), advanced crop protection agents, and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and route scouting.
• Material Science Precursor: Potential intermediate in the synthesis of specialized ligands for catalysis or functionalized polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	Methyl 5-Fluoro-4-Methylpicolinate
CAS No.	148541-72-4
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	Methyl 5-fluoro-4-methylpyridine-2-carboxylate; 5-Fluoro-4-methylpicolinic acid methyl ester; 2-Pyridinecarboxylic acid, 5-fluoro-4-methyl-, methyl ester; 5-Fluoro-4-methyl-2-pyridinecarboxylic acid methyl ester; Methyl 5-fluoro-4-methyl-2-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-Fluoro-4-Methylpicolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.