Description

Ac-Trp-3,5-Bis(Trifluoromethyl)Benzyl Ester is a specialized, high-purity protected amino acid derivative designed for advanced synthetic chemistry. This compound is a critical building block for the synthesis of complex peptides and peptidomimetics, offering precise structural control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioactive molecules.

Application

• Peptide Synthesis: Serves as a key protected tryptophan analog for solid-phase and solution-phase peptide synthesis.
• Medicinal Chemistry & Drug Discovery: Used as a sophisticated building block in the research and development of new therapeutic agents, particularly for creating analogs with enhanced metabolic stability and binding affinity.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by incorporating modified amino acids into peptide probes.
• Pharmaceutical Intermediates: Acts as a crucial intermediate in the multi-step synthesis of target drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: The benzyl ester protecting group and unique side chain make it suitable for specific conjugation strategies in bioconjugate chemistry.

Basic Information

Product Name	Ac-Trp-3,5-Bis(Trifluoromethyl)Benzyl Ester
CAS No.	148451-96-1
Molecular Formula	C23H18F6N2O3
Molecular Weight	484.39 g/mol
Synonyms	N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester; Ac-L-Trp-OBzl(3,5-CF3)2; N-Acetyltryptophan 3,5-bis(trifluoromethyl)benzyl ester; Acetyl-L-tryptophan 3,5-di(trifluoromethyl)benzyl ester; Ac-Trp-OBzl(3,5-(CF3)2); Nα-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester; Ac-Trp(OBzl-3,5-(CF3)2)-OH (protected form); L-Tryptophan, N-acetyl-, 3,5-bis(trifluoromethyl)benzyl ester
EINECS	Contact for details

Quality Control

Every batch of Ac-Trp-3,5-Bis(Trifluoromethyl)Benzyl Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and pharmaceutical development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a desiccated environment. Handle and store away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.