Description

D-Glutamic Acid, 4-Fluoro-, Dimethyl Ester, Hydrochloride, (4R)-Rel- (9Ci) is a high-purity, stereochemically defined fluorinated glutamic acid derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in providing a structurally precise, fluorinated scaffold that can impart unique metabolic stability and binding properties to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients, peptide mimetics, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially protease inhibitors, enzyme substrates, and receptor ligands.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate fluorinated glutamic acid analogs into peptides and pseudopeptides to modulate their biological activity, stability, and pharmacokinetic profile.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, or plant growth regulators with enhanced properties.
• Chemical Biology & Proteomics: Employed as a tool compound or labeled precursor in mechanistic studies and probe development to investigate enzyme function and metabolic pathways.
• Material Science Research: Potential monomer or modifier for creating specialized polymers with unique surface properties or biodegradability.
• Academic & Contract Research: A valuable reagent for methodological development in asymmetric synthesis and fluorine chemistry within university and CRO laboratories.

Basic Information

Item	Details
Product Name	D-Glutamic Acid, 4-Fluoro-, Dimethyl Ester, Hydrochloride, (4R)-Rel- (9Ci)
CAS No.	148267-92-9
Molecular Formula	C7H13FNO4 · HCl
Molecular Weight	237.64 g/mol (Free base: 193.18 g/mol)
Synonyms	(2R)-2-Amino-4-fluoropentanedioic acid dimethyl ester hydrochloride; Dimethyl (2R)-2-amino-4-fluoroglutarate hydrochloride; (4R)-rel-4-Fluoro-D-glutamic Acid Dimethyl Ester Hydrochloride; D-4-Fluoroglutamic Acid Dimethyl Ester HCl; (R)-Dimethyl 2-amino-4-fluoropentanedioate hydrochloride; Fluoroglutamic Acid Derivative; CAS 148267-92-9
EINECS	Contact for details

Quality Control

Every batch of D-Glutamic Acid, 4-Fluoro-, Dimethyl Ester, Hydrochloride, (4R)-Rel- (9Ci) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), chiral purity, and other critical parameters is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.