Description

2,2-Bis-Benzyloxymethyl-Malonic Acid Diethyl Ester is a specialized malonic acid derivative ester, serving as a versatile and protected synthetic building block in advanced organic synthesis. Its molecular structure, featuring benzyl-protected hydroxymethyl groups, makes it a critical precursor for constructing complex molecules where controlled functional group manipulation is required. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for applications such as drug discovery and the synthesis of complex natural products.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for introducing functionalized malonate units.
• Organic Synthesis Reagent: Used in C-C bond-forming reactions, such as alkylations and Michael additions, where its protected diethyl malonate structure is advantageous.
• Polymer Chemistry: Acts as a monomer or chain extender in the synthesis of specialized polyesters and other functional polymers.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating complex chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of novel organic materials with specific optical or electronic properties.
• Agrochemical Synthesis: Used as an intermediate in the research and development of new crop protection agents and herbicides.

Basic Information

Product Name	2,2-Bis-Benzyloxymethyl-Malonic Acid Diethyl Ester
CAS No.	148206-99-9
Molecular Formula	C25H32O7
Molecular Weight	444.52 g/mol
Synonyms	Diethyl 2,2-Bis(benzyloxymethyl)malonate; 2,2-Bis[(benzyloxy)methyl]propanedioic Acid Diethyl Ester; Malonic Acid, 2,2-Bis(benzyloxymethyl)-, Diethyl Ester; 2,2-Bis(benzyloxymethyl)malonic Acid Diethyl Ester; DBEDM; BBMDE; Propanedioic acid, 2,2-bis[(phenylmethoxy)methyl]-, 1,3-diethyl ester
EINECS	Contact for details

Quality Control

Every batch of 2,2-Bis-Benzyloxymethyl-Malonic Acid Diethyl Ester is produced and tested under a strict quality management system to ensure consistency and purity for demanding synthetic applications. Our standard quality assurance includes comprehensive analytical testing via HPLC, GC, NMR, and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.