Description

Benzyl 2-Amino-7-Azaspiro[3.5]Nonane-7-Carboxylate is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate, providing a rigid, three-dimensional scaffold that is highly valuable for constructing complex molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical industry for the discovery and development of new active pharmaceutical ingredients (APIs), particularly in areas targeting the central nervous system and other therapeutic modalities.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical space and optimize drug-like properties.
• Peptidomimetics Development: The spirocyclic structure is utilized to create constrained peptide analogs with enhanced metabolic stability and bioavailability.
• Ligand Synthesis for Catalysis: Acts as a precursor for chiral ligands used in asymmetric synthesis and catalysis.
• Chemical Biology Probes: Incorporated into molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects at contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	Benzyl 2-Amino-7-Azaspiro[3.5]Nonane-7-Carboxylate
CAS No.	147611-02-7
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	7-Benzyloxycarbonyl-2-amino-7-azaspiro[3.5]nonane; 2-Amino-7-azaspiro[3.5]nonane-7-carboxylic acid benzyl ester; Benzyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate; 7-CBZ-2-Amino-7-azaspiro[3.5]nonane; 2-Amino-7-azaspiro[3.5]nonane-7-carboxylate benzyl ester; 7-[(Benzyloxy)carbonyl]-2-amino-7-azaspiro[3.5]nonane; (2-Amino-7-azaspiro[3.5]nonan-7-yl)methyl benzoate (tautomeric form).
EINECS	Contact for details

Quality Control

Our Benzyl 2-Amino-7-Azaspiro[3.5]Nonane-7-Carboxylate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and pre-clinical development. We provide comprehensive analytical data including HPLC purity, chiral purity, and structural confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.