Description

2-Hydroxy-7-Aza-Spiro[3.5]Nonane-7-Carboxylic Acid Benzyl Ester is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel pharmaceuticals, particularly those targeting the central nervous system. Pharmaceutical R&D teams and fine chemical manufacturers need this high-purity intermediate to construct complex molecular architectures with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in neuroscience and psychiatric therapeutic areas.
• Protease Inhibitor Research: Used in the development of inhibitors for various protease enzymes, leveraging its rigid spirocyclic scaffold.
• Chemical Biology Probes: Serves as a core structure for creating molecular probes to study biological pathways and enzyme functions.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to introduce complex stereocenters into target molecules.
• Medicinal Chemistry: Utilized for scaffold hopping and molecular optimization in lead compound development programs.
• Academic & Industrial R&D: A valuable reagent for research institutions and companies exploring new chemical entities and intellectual property.

Basic Information

Product Name	2-Hydroxy-7-Aza-Spiro[3.5]Nonane-7-Carboxylic Acid Benzyl Ester
CAS No.	147610-99-9
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	7-Benzyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate; 2-Hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid phenylmethyl ester; Benzyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate; 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-hydroxy-, benzyl ester; 147610-99-9; Azaspiro nonane benzyl ester; Spirocyclic β-amino acid derivative
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-7-Aza-Spiro[3.5]Nonane-7-Carboxylic Acid Benzyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.