Description

3,4-o-Benzylidene-2-Methanesulfonyl-D-Ribo-1,5-Lactone is a high-value, protected carbohydrate derivative and a key chiral building block in organic synthesis. This compound matters for its role as a versatile intermediate in the production of nucleoside analogs and other complex bioactive molecules, enabling precise stereochemical control. Pharmaceutical R&D and fine chemical manufacturers need it for developing antiviral agents, anticancer drugs, and other advanced therapeutic candidates.

Application

• Pharmaceutical Intermediate: Critical chiral synthon for the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral/anticancer agents.
• Fine Chemical Synthesis: Used as a protected and activated ribose derivative in multi-step organic syntheses requiring selective functionalization.
• Carbohydrate Chemistry Research: Serves as a model compound for studying glycosylation reactions and protecting group strategies.
• Process Chemistry Development: Employed in scaling up routes to complex molecules where stereochemical integrity is paramount.
• Bioconjugate Chemistry: Potential use in the preparation of labeled sugars or sugar-protein conjugates for diagnostic applications.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs targeting RNA-based therapeutics and metabolic pathway modulators.

Basic Information

Product Name	3,4-o-Benzylidene-2-Methanesulfonyl-D-Ribo-1,5-Lactone
CAS No.	147410-07-9
Molecular Formula	C14H16O7S
Molecular Weight	328.34 g/mol
Synonyms	2-O-Methanesulfonyl-3,4-O-benzylidene-D-ribono-1,5-lactone; 2-Mesyl-3,4-O-benzylidene-D-ribonolactone; D-Ribono-1,5-lactone, 3,4-O-benzylidene-2-O-(methylsulfonyl)-; 3,4-O-Benzylidene-2-O-methanesulfonyl-D-ribono-1,5-lactone; 2-O-Mesyl-3,4-O-benzylidene-D-ribono-1,5-lactone; Benzylidene-protected ribonolactone mesylate; 147410-07-9
EINECS	Contact for details

Quality Control

Our 3,4-o-Benzylidene-2-Methanesulfonyl-D-Ribo-1,5-Lactone is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.