Description

Diethyl 3-Trifluoromethylbenzylphosphonate is a high-value organophosphorus compound, specifically a benzylphosphonate ester, widely used as a key synthetic intermediate. Its primary commercial value lies in its role as a versatile building block for the preparation of more complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active ingredients, fine chemicals, and functional materials that require the introduction of a trifluoromethylbenzylphosphonate moiety.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphonate-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of flame retardants, specialty polymers, and surface modification agents due to its phosphorus content.
• Chemical Biology Probes: Utilized to synthesize activity-based probes and inhibitors for studying phosphonate-related biochemical pathways.

Basic Information

Product Name	Diethyl 3-Trifluoromethylbenzylphosphonate
CAS No.	146780-08-7
Molecular Formula	C₁₂H₁₆F₃O₃P
Molecular Weight	296.22 g/mol
Synonyms	Diethyl (3-(trifluoromethyl)benzyl)phosphonate; (3-Trifluoromethylbenzyl)phosphonic Acid Diethyl Ester; Diethyl (3-Trifluoromethylphenyl)methylphosphonate; Phosphonic Acid, P-[(3-(Trifluoromethyl)phenyl)methyl]-, Diethyl Ester; Diethyl α-(Trifluoromethyl)benzylphosphonate; 3-Trifluoromethylbenzylphosphonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl 3-Trifluoromethylbenzylphosphonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.