Description

S-4-Bromobenzylglutathione Diethyl Ester is a synthetic, modified glutathione derivative where the thiol group is protected as an S-4-bromobenzyl ether and the carboxylic acid groups are esterified. This compound is a crucial chemical intermediate and research tool for studying glutathione metabolism, enzyme inhibition, and cellular redox processes. It is primarily utilized by pharmaceutical researchers, biochemists, and fine chemical manufacturers engaged in drug discovery and biochemical assay development.

Application

• Biochemical Research: Used as a substrate or inhibitor in studies of glutathione S-transferase (GST) enzymes and other glutathione-dependent pathways.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of more complex molecules targeting oxidative stress and detoxification mechanisms.
• Proteomics & Cell Biology: Employed as a tool compound to modulate intracellular glutathione levels and investigate apoptosis and signal transduction.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in related chemical production.
• Enzyme Kinetics: Utilized in kinetic assays to determine enzyme activity and inhibition constants for research purposes.
• Prodrug Development: Investigated for the design of prodrugs that release active glutathione or related thiols under specific biological conditions.

Basic Information

Product Name	S-4-Bromobenzylglutathione Diethyl Ester
CAS No.	146712-97-2
Molecular Formula	C₂₀H₂₉BrN₃O₆S
Molecular Weight	511.43 g/mol
Synonyms	S-(4-Bromobenzyl)glutathione Diethyl Ester; γ-Glu-Cys(4-Br-Bzl)-Gly-OEt₂; L-γ-Glutamyl-S-(4-bromobenzyl)-L-cysteinylglycine Diethyl Ester; NSC 401005; Glutathione S-(4-Bromobenzyl) Diethyl Ester; S-4-Bromobenzyl GSH Diethyl Ester; S-p-Bromobenzylglutathione Diethyl Ester
EINECS	Contact for details

Quality Control

Our S-4-Bromobenzylglutathione Diethyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets exacting research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The compound is moisture-sensitive; keep the container in a dry environment. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.