Description

tert-Butyl n-[2-Hydroxy-1,1-Bis(Hydroxymethyl)-Ethyl]Carbamate is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and stable scaffold for constructing complex molecules, particularly in the pharmaceutical and bioconjugation sectors. This compound is essential for researchers and manufacturers in peptide synthesis, medicinal chemistry, and the development of novel drug candidates and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting neurological and metabolic disorders.
• Peptide Synthesis: Used as a protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Bioconjugation Linker: Functions as a spacer or linker molecule for attaching drugs, dyes, or other functional groups to proteins, antibodies, or nanoparticles.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of novel therapeutic compounds.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) group provides orthogonal protection for amines in multi-step synthetic sequences.
• Chemical Biology Probes: Integral to the creation of molecular probes for studying biological processes and enzyme activity.

Basic Information

Product Name	tert-Butyl n-[2-Hydroxy-1,1-Bis(Hydroxymethyl)-Ethyl]Carbamate
CAS No.	146651-71-0
Molecular Formula	C10H21NO6
Molecular Weight	251.28 g/mol
Synonyms	Boc-Tris-OH; N-(tert-Butoxycarbonyl)-2-amino-2-(hydroxymethyl)-1,3-propanediol; N-Boc-2-amino-2-(hydroxymethyl)-1,3-propanediol; 2-[(tert-Butoxycarbonyl)amino]-2-(hydroxymethyl)-1,3-propanediol; 2-Amino-2-(hydroxymethyl)-1,3-propanediol, N-Boc derivative; Tris, N-Boc-; (2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[2-Hydroxy-1,1-Bis(Hydroxymethyl)-Ethyl]Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.