Description

1-Boc-2-Trimethylsilanyl-Indole is a high-value, protected indole derivative used as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in the dual protection of the indole nitrogen and the 2-position, enabling selective functionalization for the construction of complex heterocyclic systems. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and serotonin receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that utilize functionalized indole scaffolds.
• Material Science Research: Serves as a precursor for organic electronic materials and functional polymers requiring specific indole architectures.
• Academic & R&D Laboratories: A versatile reagent for methodological development in cross-coupling reactions, C-H functionalization, and total synthesis projects.
• Peptidomimetics & Bioconjugation: Facilitates the incorporation of protected indole units into peptide backbones and bioconjugate linkers.

Basic Information

Product Name	1-Boc-2-Trimethylsilanyl-Indole
CAS No.	146337-49-7
Molecular Formula	C16H25NO2Si
Molecular Weight	291.46 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-(trimethylsilyl)-1H-indole; 2-(Trimethylsilyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; 1-Boc-2-TMS-indole; tert-Butyl 2-(trimethylsilyl)-1H-indole-1-carboxylate; 2-Trimethylsilyl-1H-indole-1-carboxylic acid tert-butyl ester; 1-Boc-2-trimethylsilylindole; N-Boc-2-trimethylsilylindole; 1-Boc-2-TMSI
EINECS	Contact for details

Quality Control

Our 1-Boc-2-Trimethylsilanyl-Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for advanced intermediates, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.