Description

3-Isoxazoleaceticacid,-α--Ethylidene-,Methylester,(E)-(9Ci) is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique isoxazole-acetate structure enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to create new molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the isoxazole moiety contributes to biological efficacy.
• Fine Chemical Production: Serves as a versatile synthon for creating complex molecules in custom synthesis and contract manufacturing for various high-value applications.
• Academic & Industrial Research: Employed in chemical biology and materials science research to explore new reaction pathways and develop functional materials.
• Ligand and Catalyst Development: Potential use in designing novel ligands for asymmetric catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Isoxazoleaceticacid,-α--Ethylidene-,Methylester,(E)-(9Ci)
CAS No.	146098-65-9
Molecular Formula	C8H9NO4
Molecular Weight	183.16 g/mol
Synonyms	(E)-α-Ethylidene-3-isoxazoleacetic acid methyl ester; Methyl (E)-2-(1-ethylidene)-3-isoxazoleacetate; 3-Isoxazoleacetic acid, α-ethylidene-, methyl ester, (E)-; (E)-Methyl 2-(1-ethylidene)-1,3-oxazole-4-acetate; 146098-65-9; (E)-α-Ethylidene-3-isoxazoleacetic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Isoxazoleaceticacid,-α--Ethylidene-,Methylester,(E)-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.