Description

(R)-n-(1-Carboxyethyl)-D-Norvaline 1-Ethyl Ester CAS NO 145682-38-8 is a high-purity, non-proteinogenic amino acid derivative featuring a specific (R)-configuration and an ethyl ester protecting group. This compound is a critical chiral building block and intermediate in the synthesis of complex pharmaceuticals and bioactive peptides. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and advanced chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and neurological disorders.
• Peptide Synthesis: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis, enabling the creation of custom peptides with specific stereochemistry.
• Proteomics Research: Used as a standard or reagent in biochemical research to study enzyme mechanisms, protein interactions, and metabolic pathways.
• Chemical Biology: Employed in the design and synthesis of enzyme inhibitors, receptor ligands, and other molecular probes for drug discovery.
• Fine Chemical Production: Acts as a precursor for the manufacture of other specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Industrial R&D: Essential for methodological development in asymmetric synthesis and for exploring new chemical spaces in material science.

Basic Information

Product Name	(R)-n-(1-Carboxyethyl)-D-Norvaline 1-Ethyl Ester
CAS No.	145682-38-8
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	(R)-2-[(1-Carboxyethyl)amino]pentanoic acid ethyl ester; D-2-Ethyl 2-[(1-carboxyethyl)amino]pentanoate; (R)-N-(1-Carboxyethyl)-D-norvaline ethyl ester; Ethyl (2R)-2-[(1-carboxyethyl)amino]pentanoate; (R)-N-(1-Carboxyethyl)-D-norvaline 1-ethyl ester; D-Norvaline, N-(1-carboxyethyl)-, ethyl ester, (R)-; UNII-9J8T9Q6U4J; (R)-Ethyl 2-((1-carboxyethyl)amino)pentanoate
EINECS	Contact for details

Quality Control

Our (R)-n-(1-Carboxyethyl)-D-Norvaline 1-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We adhere to cGMP guidelines where applicable to ensure traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.