Description

Pyrrolidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise stereochemistry, enabling the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this high-value intermediate to facilitate efficient, scalable synthetic routes for target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, peptidomimetics, and other bioactive compounds.
• Agrochemical Research: Used in developing novel pesticides and herbicides with specific chiral activity.
• Peptide Chemistry: Serves as a protected proline analog for the solid-phase and solution-phase synthesis of modified peptides.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands and catalysts in enantioselective transformations.
• Material Science: A building block for specialty polymers and functional materials requiring specific molecular recognition properties.
• Academic & R&D: Utilized in medicinal chemistry research and process development for new chemical entities.

Basic Information

Product Name	Pyrrolidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester
CAS No.	145681-01-2
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidine; (2S)-1-[(2-Methyl-2-propanyl)oxycarbonyl]-2-pyrrolidinecarboxylic Acid Methyl Ester; L-Proline, 1-(1,1-dimethylethyl) 2-methyl ester; Boc-L-Proline-OMe; Boc-Pro-OMe; Methyl Boc-L-prolinate; 1-Boc-2-methyl pyrrolidine-1,2-dicarboxylate
EINECS	Contact for details

Quality Control

Our Pyrrolidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and development. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided to guarantee supply reliability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.