Description

(1α,3β,5Z,7E)-1,3-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-9,10-Secochola-5,7,10(19)-Triene-24-Carboxylic Acid Methyl Ester is a key synthetic intermediate in the production of vitamin D analogs and other high-value steroidal compounds. Its primary value lies in its role as a protected precursor molecule, enabling complex synthetic routes with high selectivity and yield. This compound is essential for pharmaceutical R&D and manufacturing, particularly for researchers and producers developing calcitriol derivatives and related therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of active vitamin D3 metabolites and analogs, such as calcitriol and its derivatives.
• Steroid Chemistry Research: Used in academic and industrial laboratories for the study and development of novel steroidal structures with potential biological activity.
• Process Chemistry: Serves as a key intermediate in the scaled-up, multi-step synthesis of target active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Employed in research to investigate vitamin D receptor (VDR) pathways and mechanisms of action.
• Custom Synthesis: Starting material for the contract manufacturing of specialized, high-purity steroidal compounds for clinical trials.

Basic Information

Product Name	(1α,3β,5Z,7E)-1,3-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-9,10-Secochola-5,7,10(19)-Triene-24-Carboxylic Acid Methyl Ester
CAS No.	145372-43-6
Molecular Formula	C36H64O4Si2
Molecular Weight	617.07 g/mol
Synonyms	1α,3β-Bis(tert-butyldimethylsilyloxy)-9,10-secocholesta-5,7,10(19)-trien-24-oic Acid Methyl Ester; Methyl 1α,3β-Bis-O-(tert-butyldimethylsilyl)-9,10-secocholesta-5,7,10(19)-trien-24-oate; 1α,3β-Bis-TBDMS Protected Vitamin D3 Intermediate; TBS-protected Vitamin D3 Methyl Ester; 1α,3β-Bis[(tert-butyldimethylsilyl)oxy]cholesta-5,7,10(19)-trien-24-oic Acid Methyl Ester; 1α,3β-Bis-O-TBDMS Vitamin D3 Methyl Ester; 1α,3β-Bis(tert-butyldimethylsilyloxy) Vitamin D3 Methyl Ester Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical development. Quality is verified through comprehensive analytical methods including HPLC, GC, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.