Description

2,3,3A,6,7,7A-Hexahydro-2S,7A-Dimethyl-4-Hydroxy-Indene-1R-(1'-Iodo)Ethane 4-o-Trifluoromethylsulfonate is a high-purity, advanced pharmaceutical intermediate characterized by its complex stereochemistry and functional groups. This compound matters for its critical role as a key chiral building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory research.
• Organic Synthesis Building Block: Utilized in complex organic transformations, including cross-coupling reactions and nucleophilic substitutions, facilitated by the reactive iodine and sulfonate ester functionalities.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development and testing of new asymmetric catalytic systems due to its defined stereocenters.
• Process Chemistry & Scale-Up: Used in process research and development (PR&D) to optimize synthetic routes for potential commercial-scale API manufacturing.
• Academic & Industrial R&D: A valuable reagent for investigating new synthetic methodologies and constructing complex molecular libraries for biological screening.

Basic Information

Product Name	2,3,3A,6,7,7A-Hexahydro-2S,7A-Dimethyl-4-Hydroxy-Indene-1R-(1'-Iodo)Ethane 4-o-Trifluoromethylsulfonate
CAS No.	145372-33-4
Molecular Formula	C₁₄H₂₀F₃IO₄S
Molecular Weight	444.27 g/mol
Synonyms	(1R,2S,3aS,7aR)-1-[(1-Iodoethyl)]-2,7a-dimethyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl trifluoromethanesulfonate; (1R,2S,3aS,7aR)-1-(1-Iodoethyl)-2,7a-dimethyloctahydro-4-indenyl Triflate; 4-(Trifluoromethanesulfonyloxy)-1R-(1'-iodoethyl)-2S,7a-dimethyl-2,3,3a,6,7,7a-hexahydro-1H-indene; Indane Triflate Iodide Derivative; Chiral Indanyl Triflate Intermediate; CAS 145372-33-4.
EINECS	Contact for details

Quality Control

Our 2,3,3A,6,7,7A-Hexahydro-2S,7A-Dimethyl-4-Hydroxy-Indene-1R-(1'-Iodo)Ethane 4-o-Trifluoromethylsulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled with appropriate precautions for strong acid/organic solvent. Keep container tightly sealed when not in use to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.