Description

Benzyl n-(Diphenylmethylene)-L-Serinate CAS NO 145362-72-7 is a high-purity, protected amino acid derivative primarily used as a critical chiral building block in advanced organic synthesis. This compound is essential for the controlled introduction of serine into complex molecular architectures, enabling the production of high-value, optically active products. It is particularly valuable for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for peptide synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate serine residues while protecting reactive side chains.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing combinatorial libraries and exploring structure-activity relationships (SAR).
• Agrochemical Development: Employed in the synthesis of chiral active ingredients for herbicides and fungicides.
• Asymmetric Synthesis: Utilized in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Bioconjugation: Acts as a precursor for linkers and spacers in antibody-drug conjugates (ADCs) and other bioconjugation strategies.

Basic Information

Product Name	Benzyl n-(Diphenylmethylene)-L-Serinate
CAS No.	145362-72-7
Molecular Formula	C23H21NO3
Molecular Weight	359.42 g/mol
Synonyms	Benzyl (S)-2-[(Diphenylmethylene)amino]-3-hydroxypropanoate; L-Serine, N-(diphenylmethylene)-, benzyl ester; (S)-Benzyl 2-((diphenylmethylene)amino)-3-hydroxypropanoate; N-(Diphenylmethylene)-L-serine benzyl ester; Benzyl N-(diphenylmethylidene)-L-serinate; Serine, N-(diphenylmethylene)-, benzyl ester, L-; Protected L-Serine benzyl ester; Chiral serine derivative
EINECS	Contact for details

Quality Control

Our Benzyl n-(Diphenylmethylene)-L-Serinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.