Description

Benzoic Acid (2S,4S,4'R)-2',2'-Dimethyl-[4,4']Bi[[1,3]Dioxolanyl]-2-Ylmethyl Ester CAS NO 145354-79-6 is a high-purity, chiral benzoic acid derivative featuring a complex, protected diol structure. This compound is a critical advanced intermediate in the synthesis of complex pharmaceuticals and fine chemicals, where its defined stereochemistry is essential for biological activity. It is primarily required by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, or neurological drugs.
• Asymmetric Synthesis: Used as a stereochemically defined starting material or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Fine Chemical Production: Serves as a precursor in the manufacture of high-value specialty chemicals, flavors, and fragrances requiring specific enantiomeric purity.
• Agrochemical Research: Employed in the development of new, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: Utilized in research programs focused on methodology development, total synthesis, and exploring new chemical entities.
• Process Chemistry: Investigated for scale-up in pilot plants and commercial manufacturing processes for target molecules.

Basic Information

Product Name	Benzoic Acid (2S,4S,4'R)-2',2'-Dimethyl-[4,4']Bi[[1,3]Dioxolanyl]-2-Ylmethyl Ester
CAS No.	145354-79-6
Molecular Formula	C24H26O8
Molecular Weight	442.46 g/mol
Synonyms	(2S,4S,4'R)-2',2'-Dimethyl-[4,4']bi[1,3]dioxolanyl-2-ylmethyl benzoate; Benzoic acid, (2S,4S,4'R)-2',2'-dimethyl-[4,4']bi[1,3]dioxolanyl-2-ylmethyl ester; (2S,4S,4'R)-2',2'-Dimethyl-[4,4']-bi-1,3-dioxolanyl-2-ylmethyl benzoate; (2S,4S,4'R)-2',2'-Dimethyl-4,4'-bi-1,3-dioxolane-2-ylmethyl benzoate; Chiral benzoic acid dioxolane ester; (2S,4S,4'R)-DMDBA ester; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and chiral integrity. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccant or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.