Description

2-(Triisopropylsilyl)-1,3-Dithiane 97 is a high-purity organosilicon-protected dithiane reagent, a critical building block in advanced organic synthesis. Its primary value lies in its role as a robust, sterically hindered protecting group for carbonyl compounds and as a versatile nucleophile in C-C bond-forming reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for complex molecule construction.

Application

• Carbonyl Protection in Total Synthesis: Serves as a key reagent for the temporary protection of aldehyde and ketone functionalities in multi-step syntheses of complex natural products and active pharmaceutical ingredients (APIs).
• Nucleophilic Alkylation Reactions: Acts as a stabilized carbanion equivalent (umpolung) for the introduction of acyl anion synthons, enabling the construction of challenging carbon skeletons.
• Asymmetric Synthesis: Used in the preparation of chiral auxiliaries and intermediates where the bulky triisopropylsilyl (TIPS) group provides excellent stereocontrol.
• Material Science Precursors: Employed in the synthesis of novel organic ligands and functional molecules for advanced materials research.
• Process Chemistry Development: Valued for its stability and handling characteristics in scaling up synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	2-(Triisopropylsilyl)-1,3-Dithiane 97
CAS No.	145251-89-4
Molecular Formula	C15H32S2Si
Molecular Weight	304.63 g/mol
Synonyms	2-(Triisopropylsilyl)-1,3-dithiane; 1,3-Dithiane, 2-(triisopropylsilyl)-; TIPS-Dithiane; 2-TIPS-1,3-dithiane; Triisopropylsilyl dithiane; 2-(Triisopropylsilyl)dithiane; Carbonyl equivalent TIPS-dithiane; 2-(Triisopropylsilyl)-1,3-dithian
EINECS	Contact for details

Quality Control

Every batch of 2-(Triisopropylsilyl)-1,3-Dithiane 97 undergoes rigorous analytical testing to ensure it meets the high standards required for synthetic chemistry. Our quality assurance protocols include identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.