Description

(1S,2S)-trans-n-Boc-2-Aminocyclopentanol CAS NO 145106-43-0 is a high-purity, chiral building block featuring a Boc-protected amino group and a hydroxyl group on a cyclopentane scaffold. This compound is critically important for its role in the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other small-molecule therapeutics.
• Peptidomimetics Construction: Used to introduce constrained, cyclic amino acid analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts.
• Agrochemical Synthesis: Employed in the research and production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & R&D: A valuable reagent for methodological studies in organic synthesis and medicinal chemistry programs.
• Custom Synthesis Building Block: Provided for contract research organizations (CROs) and CDMOs for client-specific projects requiring this specific stereochemistry.

Basic Information

Product Name	(1S,2S)-trans-n-Boc-2-Aminocyclopentanol
CAS No.	145106-43-0
Molecular Formula	C₁₀H₁₉NO₃
Molecular Weight	201.26 g/mol
Synonyms	(1S,2S)-1-[(tert-Butoxycarbonyl)amino]-2-hydroxycyclopentane; (1S,2S)-2-(Boc-amino)cyclopentanol; (1S,2S)-N-Boc-2-aminocyclopentanol; trans-(1S,2S)-2-(tert-Butoxycarbonylamino)cyclopentanol; (1S,2S)-rel-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclopentanol; tert-Butyl (1S,2S)-2-hydroxycyclopentylcarbamate; BOC-(1S,2S)-ACPO; (1S,2S)-Boc-ACPA
EINECS	Contact for details

Quality Control

Our (1S,2S)-trans-n-Boc-2-Aminocyclopentanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR, IR, MS) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.