Description

(S)-(-)-2-Isocyanatoglutaric Acid Diethyl Ester is a high-value, chiral isocyanate derivative of glutamic acid. This compound serves as a critical chiral building block and versatile intermediate in the synthesis of complex organic molecules, enabling the introduction of both isocyanate and ester functionalities with precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry, asymmetric synthesis, and the production of peptidomimetics and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor research.
• Peptidomimetic Synthesis: Used to construct non-peptide scaffolds that mimic the structure and function of natural peptides, enhancing metabolic stability.
• Asymmetric Synthesis: Employed in stereoselective reactions to create enantiomerically pure compounds for advanced material and drug discovery.
• Chemical Biology Probes: Acts as a reactive handle for labeling and modifying biomolecules to study biological pathways and protein function.
• Polymer Science: Can be utilized as a monomer or cross-linking agent in the synthesis of specialized polyurethanes and polymers with tailored properties.
• Agrochemical Research: Serves as an intermediate in the design and synthesis of new chiral agrochemicals with improved efficacy and selectivity.

Basic Information

Product Name	(S)-(-)-2-Isocyanatoglutaric Acid Diethyl Ester
CAS No.	145080-95-1
Molecular Formula	C10H15NO5
Molecular Weight	229.23 g/mol
Synonyms	(S)-2-Isocyanatopentanedioic Acid Diethyl Ester; Diethyl (S)-2-Isocyanatoglutarate; L-2-Isocyanatoglutaric Acid Diethyl Ester; (S)-Diethyl 2-Isocyanatoglutarate; Glutaric Acid, 2-Isocyanato-, Diethyl Ester, (S)-; (S)-(-)-Diethyl 2-Isocyanatoglutarate; (2S)-2-Isocyanatopentanedioic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our (S)-(-)-2-Isocyanatoglutaric Acid Diethyl Ester is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation (IR, NMR). We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.