Description

(S)-(+)-2-Isocyanato-3-tert-Butoxypropionic Acid Methyl Ester is a high-value, chiral isocyanate derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in introducing the isocyanate functional group with stereochemical control, enabling the creation of complex molecules with defined three-dimensional structures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients, chiral auxiliaries, and specialized polymers.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other bioactive molecules requiring stereospecificity.
• Agrochemical Synthesis: Building block for developing chiral herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Peptide Mimetics & Linkers: Used in the preparation of peptidomimetics and for introducing urethane or urea linkages in drug conjugates and bioconjugates.
• Chiral Polymer Synthesis: Monomer for producing specialized polyurethanes and polyisocyanates with optical activity for advanced material applications.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes (ABPs) and other research tools for studying enzyme function.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other catalytic transformations.

Basic Information

Product Name	(S)-(+)-2-Isocyanato-3-tert-Butoxypropionic Acid Methyl Ester
CAS No.	145080-94-0
Molecular Formula	C10H17NO5
Molecular Weight	231.25 g/mol
Synonyms	Methyl (S)-2-isocyanato-3-(tert-butoxy)propanoate; (S)-Methyl 2-isocyanato-3-(tert-butoxy)propanoate; (S)-(+)-2-Isocyanato-3-tert-butoxypropionic acid methyl ester; L-2-Isocyanato-3-tert-butoxypropionic acid methyl ester; (S)-2-Isocyanato-3-(tert-butoxy)propionic acid methyl ester; tert-Butyl (S)-2-isocyanato-3-methoxy-3-oxopropyl ether; (S)-Methyl 3-(tert-butoxy)-2-isocyanatopropanoate
EINECS	Contact for details

Quality Control

Our (S)-(+)-2-Isocyanato-3-tert-Butoxypropionic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original sealed packaging to prevent degradation from moisture and to maintain reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.