Description

4H-Inden-4-One, 1-[1,5-Dimethyl-5-[(Triethylsilyl)Oxy]Hexyl]Octahydro-7A-Methyl-, [1R-[1α(R*),3Aβ,7Aα]]- is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral building block in the development of complex, biologically active molecules, offering precise control over molecular architecture. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of proprietary drug candidates, particularly in oncology and metabolic disease research.
• Advanced Organic Synthesis: Serves as a versatile building block for constructing complex polycyclic frameworks and natural product analogs in academic and industrial laboratories.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new stereoselective synthetic methodologies.
• Material Science Research: Potential monomer or precursor for the synthesis of specialized polymers with unique optical or electronic properties.

Basic Information

Product Name	4H-Inden-4-One, 1-[1,5-Dimethyl-5-[(Triethylsilyl)Oxy]Hexyl]Octahydro-7A-Methyl-, [1R-[1α(R*),3Aβ,7Aα]]-
CAS No.	144848-24-8
Molecular Formula	C26H48O2Si
Molecular Weight	420.75 g/mol
Synonyms	(1R,3aS,7aR)-1-[(1R)-1,5-Dimethyl-5-[(triethylsilyl)oxy]hexyl]octahydro-7a-methyl-4H-inden-4-one; (1R,3aS,7aR)-1-[(1R)-1,5-Dimethyl-5-(triethylsilyloxy)hexyl]octahydro-7a-methyl-4H-inden-4-one; 4H-Inden-4-one, 1-[1,5-dimethyl-5-[(triethylsilyl)oxy]hexyl]octahydro-7a-methyl-, [1R-[1α(R*),3aβ,7aα]]-; Chiral Triethylsilyl-Protected Indanone Derivative; TIPS-Indanone Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4H-Inden-4-One derivative is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes rigorous analytical testing, including HPLC for chiral purity and assay, to meet the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) with full analytical data, including stereochemical confirmation, are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.