Description

Methyl 2-Bromo-6-(Trifluoromethyl)Nicotinate is a high-purity, synthetically valuable halogenated nicotinate derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with trifluoromethyl and bromo functionalities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the biological activity of the trifluoromethylpyridine core.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and liquid crystals with unique electronic properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new heterocyclic chemistry and fluorinated compounds.
• Ligand Synthesis: Used to prepare complex ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Methyl 2-Bromo-6-(Trifluoromethyl)Nicotinate
CAS No.	144740-56-7
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	2-Bromo-6-(trifluoromethyl)nicotinic acid methyl ester; Methyl 2-bromo-6-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-bromo-6-(trifluoromethyl)-, methyl ester; 2-Bromo-6-trifluoromethyl-nicotinic acid methyl ester; Methyl 2-bromo-6-trifluoromethylnicotinate; 144740-56-7; Methyl 2-bromo-6-(trifluoromethyl)-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-6-(Trifluoromethyl)Nicotinate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, and our quality systems are designed to meet the rigorous demands of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.