Description

1,7-Diazaspiro[4.4]Nonane-2,6-Dione,8-Hydroxy-,(5R-Cis)-(9Ci) is a high-purity, stereochemically defined spirocyclic compound serving as a critical advanced intermediate in modern organic synthesis. Its unique fused bicyclic structure with a hydroxyl group makes it a valuable building block for constructing complex molecules with specific three-dimensional architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Used in the synthesis of novel, high-performance pesticides and herbicides where its spirocyclic core contributes to unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic and R&D Laboratories: Employed in methodological studies and the construction of complex natural product analogs and molecular scaffolds.
• Fine Chemical Production: Integral in the multi-step synthesis of specialty chemicals for electronics, materials science, and other high-tech industries.

Basic Information

Product Name	1,7-Diazaspiro[4.4]Nonane-2,6-Dione,8-Hydroxy-,(5R-Cis)-(9Ci)
CAS No.	144540-04-5
Molecular Formula	C7H8N2O3
Molecular Weight	168.15 g/mol
Synonyms	(5R,8R)-8-Hydroxy-1,7-diazaspiro[4.4]nonane-2,6-dione; (5R-cis)-8-Hydroxy-1,7-diazaspiro[4.4]nonane-2,6-dione; 8-Hydroxy-1,7-diazaspiro[4.4]nonane-2,6-dione (5R-cis); Spirocyclic hydantoin derivative; Hydroxylated diazaspiro compound; Chiral spiro hydantoin
EINECS	Contact for details

Quality Control

Our production of 1,7-Diazaspiro[4.4]Nonane-2,6-Dione,8-Hydroxy-,(5R-Cis)-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), chiral purity, and impurity profile is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.