Description

2-Azetidinecarboxylicacid,3-(1-Methylethyl)-4-Oxo-,Methylester,cis-(9Ci) is a specialized heterocyclic building block featuring a constrained azetidine ring system. This compound is valued for its unique stereochemistry and functional groups, which make it a critical intermediate in advanced organic synthesis. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. The cis-configuration of the substituents provides distinct spatial orientation for structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of protease inhibitors, β-lactam analogs, and other nitrogen-containing therapeutic agents.
• Medicinal Chemistry Research: Used in high-throughput screening and lead optimization for creating novel molecular scaffolds with potential biological activity.
• Agrochemical Synthesis: Intermediate in the development of advanced pesticides and herbicides that require specific stereochemistry for efficacy.
• Peptidomimetics: Serves as a constrained amino acid analog in the design of peptide mimics to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the creation of tool compounds and probes for studying enzyme mechanisms and protein-ligand interactions.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic synthesis, particularly in ring-forming and stereoselective reactions.

Basic Information

Product Name	2-Azetidinecarboxylicacid,3-(1-Methylethyl)-4-Oxo-,Methylester,cis-(9Ci)
CAS No.	144452-35-7
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	cis-3-Isopropyl-4-oxoazetidine-2-carboxylic acid methyl ester; Methyl cis-3-isopropyl-4-oxoazetidine-2-carboxylate; 2-Azetidinecarboxylic acid, 3-(1-methylethyl)-4-oxo-, methyl ester, (2R,3S)-rel-; Azetidine-2-carboxylic acid, 3-isopropyl-4-oxo-, methyl ester, cis-; (2R,3S)-3-Isopropyl-4-oxoazetidine-2-carboxylic acid methyl ester (relative); 144452-35-7; cis-3-Isopropyl-4-oxo-2-azetidinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific research or development project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.