Description

5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, (4R,8S)-Rel- is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and bicyclic lactam structure. This compound is of significant commercial value for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the global pharmaceutical and biotechnology sectors for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of complex drug molecules, particularly those targeting the central nervous system.
• Protease Inhibitor Synthesis: Serves as a core structural component in the development of novel protease inhibitors for antiviral and anticancer therapies.
• Peptidomimetic Chemistry: Used in the design and synthesis of peptidomimetics, which are crucial for creating metabolically stable drug candidates.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic processes to introduce stereochemical complexity.
• Medicinal Chemistry R&D: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: Utilized by fine chemical manufacturers for the contract synthesis of bespoke, high-value compounds for client projects.

Basic Information

Product Name	5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, (4R,8S)-Rel-
CAS No.	144373-59-1
Molecular Formula	C8H9NO5
Molecular Weight	199.16 g/mol
Synonyms	(4R,8S)-rel-5-Oxa-2-azaspiro[3.5]nonane-8-carboxylic acid, 1,6-dioxo-; (4R,8S)-rel-1,6-Dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylic acid; 5-Oxa-2-azaspiro[3.5]nonane-8-carboxylic acid, 1,6-dioxo-, (4R,8S)-rel-; Bicyclic Lactam Acid; Spirocyclic Lactam Intermediate; rel-(4R,8S)-1,6-Dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, (4R,8S)-Rel- is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Every lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.