Description

5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, (4R,8R)-Rel- is a high-purity, stereochemically defined spirocyclic compound that serves as a critical chiral building block in advanced organic synthesis. Its unique fused bicyclic structure, featuring both lactam and lactone functionalities, makes it an invaluable intermediate for constructing complex molecular architectures with precise stereochemical control. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in protease inhibitor programs.
• Agrochemical Synthesis: Used in the construction of advanced, stereospecific active ingredients for crop protection products.
• Chemical Biology & Proteomics: Employed as a scaffold or building block for designing activity-based probes and enzyme inhibitors.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of novel chiral ligands and organocatalysts.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in spirocycle and heterocycle formation.
• Peptidomimetics Development: Its structure mimics peptide turn motifs, making it useful for creating stable peptidomimetic compounds.

Basic Information

Product Name	5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, (4R,8R)-Rel-
CAS No.	144373-58-0
Molecular Formula	C8H9NO5
Molecular Weight	199.16 g/mol
Synonyms	rel-(4R,8R)-1,6-Dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylic acid; (4R,8R)-rel-1,6-Dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylic acid; 5-Oxa-2-azaspiro[3.5]nonane-8-carboxylic acid, 1,6-dioxo-, (4R,8R)-rel-; Spirocyclic glutarimide derivative; Chiral spiro β-lactam-γ-lactone
EINECS	Contact for details

Quality Control

Our production of 5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, (4R,8R)-Rel- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.