Description

5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, Phenylmethyl Ester, (4R,8S)-Rel- is a high-purity, stereochemically defined spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a sophisticated chiral intermediate, providing a rigid, functionalized scaffold that is critical for constructing complex molecular architectures with precise three-dimensional control. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in the areas of protease inhibitors and other biologically active small molecules where its unique spirocyclic and lactam-lactone fused structure offers distinct advantages.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Synthesis: Used in the design and synthesis of novel, high-performance pesticides and herbicides that require specific stereochemistry for optimal activity.
• Advanced Material Precursor: Serves as a specialized building block for creating polymers or functional materials with tailored properties derived from its spirocyclic core.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis to explore novel chemical space and biological activity.
• Asymmetric Synthesis Catalyst/ Ligand Development: Its chiral structure can be utilized to derive novel ligands or organocatalysts for enantioselective transformations.
• Chemical Biology Probe Synthesis: Used to create molecular probes for studying biological pathways and protein function due to its ability to mimic constrained peptide motifs.

Basic Information

Item	Details
Product Name	5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, Phenylmethyl Ester, (4R,8S)-Rel-
CAS No.	144373-57-9
Molecular Formula	C15H15NO5
Molecular Weight	289.28 g/mol
Synonyms	rel-(4R,8S)-1,6-Dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylic acid phenylmethyl ester; Benzyl (4R,8S)-rel-1,6-dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylate; (4R,8S)-rel-5-Oxa-2-azaspiro[3.5]nonane-8-carboxylic acid, 1,6-dioxo-, benzyl ester; Spirocyclic glutarimide-lactone benzyl ester; 144373-57-9; Benzyl 1,6-dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylate (rel-(4R,8S)-form)
EINECS	Contact for details

Quality Control

Every batch of our 5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, Phenylmethyl Ester, (4R,8S)-Rel- is produced and tested under strict quality management systems. We ensure high chiral purity and chemical integrity through advanced analytical techniques including HPLC, GC, and NMR. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e. (for specified enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.