Description

5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, Phenylmethyl Ester, (4R,8R)-Rel- is a high-purity, stereochemically defined spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a sophisticated chiral intermediate, providing a rigid, functionalized scaffold that is critical for constructing complex molecular architectures with precise spatial orientation. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space due to its constrained spirocyclic structure.
• Process Chemistry Development: Employed in route scouting and scale-up synthesis for the production of advanced intermediates under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Acts as a precursor for developing new generation pesticides and herbicides with specific chiral activity.
• Academic Research: Utilized in methodological studies for novel spirocycle formation and asymmetric synthesis techniques.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Item	Detail
Product Name	5-Oxa-2-Azaspiro[3.5]Nonane-8-Carboxylic Acid, 1,6-Dioxo-, Phenylmethyl Ester, (4R,8R)-Rel-
CAS No.	144373-56-8
Molecular Formula	C15H15NO5
Molecular Weight	289.28 g/mol
Synonyms	rel-(4R,8R)-Benzyl 1,6-dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylate; Benzyl (4R,8R)-rel-1,6-dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylate; 5-Oxa-2-azaspiro[3.5]nonane-8-carboxylic acid, 1,6-dioxo-, phenylmethyl ester, (4R,8R)-rel-; (4R,8R)-rel-5-Oxa-2-azaspiro[3.5]nonane-8-carboxylic acid, 1,6-dioxo-, benzyl ester; Spirocyclic glutarimide derivative; Benzyl rel-(4R,8R)-1,6-dioxo-5-oxa-2-azaspiro[3.5]nonane-8-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment. We support development under GMP-grade requirements for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.