Description

Methanol, [(1,1-Dimethylethyl)dimethylsilyl]- is a specialized organosilicon-protected methanol derivative, also known as tert-butyldimethylsilyl (TBDMS) methyl ether. This compound is a crucial reagent in synthetic organic chemistry, valued for its role as a robust protecting group for hydroxyl functions. It is primarily needed by research and development laboratories, pharmaceutical intermediates manufacturers, and fine chemical producers engaged in multi-step synthesis where precise control over functional group reactivity is essential.

Application

• Pharmaceutical Intermediate Synthesis: Used as a protecting group reagent for alcohols and phenols during the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide and Oligonucleotide Chemistry: Protects sensitive hydroxyl groups on nucleosides, sugars, and amino acid side chains, preventing unwanted side reactions.
• Natural Product and Total Synthesis: Enables selective protection strategies in the multi-step synthesis of complex natural products and target molecules.
• Material Science Research: Serves as a precursor or modifying agent in the development of specialty silicone-based polymers and surface coatings.
• Process Development & Scale-up: Employed in kilo-lab and pilot plant operations for the development of robust and scalable chemical processes.

Basic Information

Product Name	Methanol, [(1,1-Dimethylethyl)dimethylsilyl]-
CAS No.	144314-37-4
Molecular Formula	C7H18OSi
Molecular Weight	146.30 g/mol
Synonyms	tert-Butyldimethylsilyl Methyl Ether; TBDMS Methyl Ether; (tert-Butyldimethylsilyloxy)methane; Methoxy(tert-butyl)dimethylsilane; tert-Butyl(dimethyl)(methoxy)silane; TBS Methyl Ether; O-Methyl tert-butyldimethylsilyl Ether
EINECS	Contact for details

Quality Control

Our Methanol, [(1,1-Dimethylethyl)dimethylsilyl]- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.