Description

L-Glutamic Acid 1-tert-Butyl Ester Hydrochloride is a protected amino acid derivative essential for advanced organic synthesis. This compound is a critical building block in the production of complex peptides and active pharmaceutical ingredients (APIs), offering a strategic combination of reactivity and stability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and biochemical tools.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis, where the tert-butyl ester group provides orthogonal protection for the glutamic acid side chain.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of new drug candidates, particularly in oncology, neurology, and metabolic disease research.
• Bioconjugation & Linker Chemistry: Used in the design and synthesis of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Biochemical Research: Employed in the study of enzyme mechanisms, receptor-ligand interactions, and the synthesis of custom amino acid analogs for proteomics.
• Fine Chemical Production: Acts as a specialized intermediate for synthesizing complex organic molecules with high added value in agrochemical and material science applications.

Basic Information

Product Name	L-Glutamic Acid 1-tert-Butyl Ester Hydrochloride
CAS No.	144313-55-3
Molecular Formula	C9H18ClNO4
Molecular Weight	239.70 g/mol
Synonyms	H-Glu(OtBu)-OH·HCl; L-Glutamic acid 5-tert-butyl ester hydrochloride; (S)-2-Amino-5-(tert-butoxy)-5-oxopentanoic acid hydrochloride; tert-Butyl L-glutamate hydrochloride; Glutamic acid 1-tert-butyl ester hydrochloride; Boc-Glu(OtBu)-OH (Note: This is a common misnomer; the Boc group is not present); H-Glu(OtBu)-OH hydrochloride salt
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid 1-tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.