Description

(S)-7-Amino-5-Benzyl-4-Oxo-5-Azaspiro[2.4]Heptane is a high-purity, chiral spirocyclic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas. It is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality chiral intermediates to accelerate drug discovery pipelines and ensure scalable, reproducible synthesis.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for neurological and psychiatric targets.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce stereochemical complexity into target molecules.
• Process Chemistry & Scale-Up: Serves as a building block for developing robust and cost-effective commercial-scale synthetic routes to APIs.
• Protease Inhibitor Development: Potential utility in the design of inhibitors targeting specific enzyme families due to its spirocyclic β-amino acid-like structure.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-7-Amino-5-Benzyl-4-Oxo-5-Azaspiro[2.4]Heptane
CAS No.	144282-41-7
Molecular Formula	C14H18N2O
Molecular Weight	230.31 g/mol
Synonyms	(5S)-7-Amino-5-benzyl-4-oxo-5-azaspiro[2.4]heptane; (S)-7-Amino-5-benzyl-4-oxo-5-azaspiro[2.4]heptane; 5-Azaspiro[2.4]heptane-7-amine, 5-benzyl-4-oxo-, (5S)-; 144282-41-7; (S)-5-Benzyl-7-amino-4-oxo-5-azaspiro[2.4]heptane; Spirocyclic β-amino acid derivative; Chiral azaspiroheptane building block
EINECS	Contact for details

Quality Control

Our (S)-7-Amino-5-Benzyl-4-Oxo-5-Azaspiro[2.4]Heptane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable and can provide material for regulatory filing support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.