Description

Fmoc-Glu-Oall CAS NO 144120-54-7 is a protected amino acid derivative, specifically the O-allyl ester of N-α-Fmoc-L-glutamic acid, which is a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled and sequential assembly of peptides, enabling the synthesis of complex biomolecules for research and therapeutic development. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in peptide chemistry and drug discovery.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the incorporation of glutamic acid residues using Fmoc/tert-butyl or Fmoc/allyl protection strategies.
• Peptide Drug Discovery: Used in the research and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation and Labeling: The allyl ester protecting group allows for orthogonal deprotection, enabling selective modification and labeling of peptide side chains.
• Academic and Industrial Research: Fundamental tool for studying protein structure-function relationships, enzyme-substrate interactions, and signal transduction pathways.
• Synthesis of Glutamate-Containing Peptides: Specifically designed for the efficient and high-fidelity introduction of glutamic acid, which is often involved in catalytic sites and molecular recognition.

Basic Information

Product Name	Fmoc-Glu-Oall
CAS No.	144120-54-7
Molecular Formula	C₂₄H₂₅NO₆
Molecular Weight	423.46 g/mol
Synonyms	Fmoc-L-glutamic acid 1-allyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 1-allyl ester; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]pentanedioic acid 5-allyl ester; Fmoc-Glu(OAll)-OH; Fmoc-L-Glu(OAll)-OH; N-α-Fmoc-L-glutamic acid γ-allyl ester; Allyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamate
EINECS	Contact for details

Quality Control

Our Fmoc-Glu-Oall is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.