Description

L-Aspartic Acid, 1-(Hydroxymethyl) Ester (9Ci) is a specialized derivative of the amino acid L-aspartic acid, featuring a hydroxymethyl ester modification. This functionalization makes it a valuable chiral building block and intermediate for the synthesis of more complex bioactive molecules and fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery, peptide synthesis, and the development of novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in peptide-based therapeutics and enzyme inhibitors.
• Peptide Synthesis: Used as a protected or modified aspartic acid derivative in solid-phase and solution-phase peptide synthesis to introduce specific functionalities.
• Bioconjugation & Linker Chemistry: The hydroxymethyl ester group serves as a handle for bioconjugation strategies, useful in creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Agrochemical Research: Employed as an intermediate in the synthesis of novel herbicides, fungicides, or plant growth regulators that utilize amino acid analogs.
• Biochemical Research: Utilized in enzymatic studies and as a substrate analog to investigate metabolic pathways involving aspartic acid.
• Fine Chemical Synthesis: Serves as a building block for synthesizing specialty chemicals, including chiral ligands for catalysis and advanced polymer precursors.

Basic Information

Product Name	L-Aspartic Acid, 1-(Hydroxymethyl) Ester (9Ci)
CAS No.	143977-10-0
Molecular Formula	C5H9NO5
Molecular Weight	163.13 g/mol
Synonyms	1-(Hydroxymethyl) L-aspartate; L-Aspartic acid 1-(hydroxymethyl) ester; (S)-1-(Hydroxymethyl) 4-amino-1,4-dioxobutane-1-carboxylate; Aspartic acid β-(hydroxymethyl) ester; L-Aspartic acid hydroxymethyl ester; 4-Amino-1,4-dioxo-1-butanol-1-carboxylic acid, (S)-; 9CI Identifier Name
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid, 1-(Hydroxymethyl) Ester (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.