Description

Carbamic Acid, (2-Fluorocyclopropyl)-, 1,1-Dimethylethyl Ester, (1R-Trans)- (9Ci) is a high-purity, stereochemically defined fluorinated cyclopropane derivative used as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) where the fluorocyclopropyl moiety can significantly influence biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and CNS-active compounds.
• Agrochemical Synthesis: Used in the construction of advanced fluorinated active ingredients for crop protection products, where the cyclopropane ring can enhance efficacy and environmental profile.
• Methodology Development: Serves as a valuable substrate in academic and industrial research for developing new asymmetric synthesis and fluorination methodologies.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized chiral ligands or organocatalysts that incorporate the fluorocyclopropyl motif for stereoselective transformations.
• Material Science Precursor: Potential use as a monomer or functionalization agent for creating fluorinated polymers with unique surface properties or stability.

Basic Information

Product Name	Carbamic Acid, (2-Fluorocyclopropyl)-, 1,1-Dimethylethyl Ester, (1R-Trans)- (9Ci)
CAS No.	143840-33-9
Molecular Formula	C9H16FNO2
Molecular Weight	189.23 g/mol
Synonyms	(1R,2S)-2-Fluorocyclopropanecarbamic acid tert-butyl ester; tert-Butyl N-[(1R,2S)-2-fluorocyclopropyl]carbamate; (1R-trans)-N-(tert-Butoxycarbonyl)-2-fluorocyclopropanamine; BOC-(1R,2S)-2-fluorocyclopropylamine; (1R,2S)-2-Fluoro-1-cyclopropanamine, N-BOC-protected; trans-N-Boc-2-fluorocyclopropylamine; (1R,2S)-tert-Butyl 2-fluorocyclopropylcarbamate
EINECS	Contact for details

Quality Control

Our Carbamic Acid, (2-Fluorocyclopropyl)-, 1,1-Dimethylethyl Ester, (1R-Trans)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.