Description

(2S,3R,4R,5S)-Methyl 3,4-Dihydroxy-5-Methyltetrahydrofuran-2-Carboxylate is a high-purity, stereochemically defined carbohydrate derivative and a key chiral building block in organic synthesis. Its precise stereochemistry makes it an invaluable intermediate for the development of complex, biologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of nucleoside analogs, antiviral agents, and other fine chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Antiviral Drug Research: Serves as a foundational scaffold in the development of next-generation antiviral therapeutics targeting viral polymerases.
• Carbohydrate Chemistry: Used in the stereoselective synthesis of complex sugars, glycomimetics, and other natural product derivatives.
• Chemical Biology Probes: Employed in the creation of labeled or modified nucleosides for studying enzymatic mechanisms and cellular processes.
• Process Chemistry Development: Utilized in route scouting and optimization for the large-scale production of chiral active pharmaceutical ingredients (APIs).
• Academic & Contract Research: A valuable reagent for methodological studies in asymmetric synthesis and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	(2S,3R,4R,5S)-Methyl 3,4-Dihydroxy-5-Methyltetrahydrofuran-2-Carboxylate
CAS No.	143813-45-0
Molecular Formula	C8H14O6
Molecular Weight	206.19 g/mol
Synonyms	Methyl (2S,3R,4R,5S)-3,4-dihydroxy-5-methyltetrahydrofuran-2-carboxylate; 5-Methyl-3,4-dihydroxytetrahydrofuran-2-carboxylic acid methyl ester; (2S,3R,4R,5S)-5-Methyl tetrahydrofuran-2,3,4-triol 2-carboxylic acid methyl ester; Methyl 3,4-dihydroxy-5-methyltetrahydro-2-furoate; A chiral tetrahydrofuran carboxylate derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of (2S,3R,4R,5S)-Methyl 3,4-Dihydroxy-5-Methyltetrahydrofuran-2-Carboxylate adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and optical rotation to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to ensure full traceability and support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	To be provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.