Description

Propanedioic Acid, (2,5-Dioxo-1-Pyrrolidinyl)-, Diethyl Ester is a high-purity, specialty chemical building block. This compound is valued for its role as a versatile active ester intermediate in advanced organic synthesis. It is primarily needed by research and development laboratories, pharmaceutical manufacturers, and fine chemical producers for applications in peptide coupling, polymer chemistry, and the synthesis of complex bioactive molecules.

Application

• Peptide Synthesis: Acts as an efficient coupling agent or protected amino acid derivative in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Serves as a key building block in the production of active pharmaceutical ingredients (APIs) and drug candidates.
• Polymer Modification: Used to introduce functional succinimidyl ester groups into polymers for creating biocompatible materials, drug delivery systems, and functional surfaces.
• Bioconjugation: Facilitates the covalent linking of proteins, antibodies, or other biomolecules with dyes, drugs, or solid supports for diagnostic and therapeutic applications.
• Cross-linking Agent: Employed in the preparation of hydrogels, cross-linked proteins, and other macromolecular networks.
• Organic Synthesis Reagent: Utilized as a versatile reagent for amide bond formation under mild conditions in complex molecule assembly.

Basic Information

Product Name	Propanedioic Acid, (2,5-Dioxo-1-Pyrrolidinyl)-, Diethyl Ester
CAS No.	143801-19-8
Molecular Formula	C11H15NO6
Molecular Weight	257.24 g/mol
Synonyms	Diethyl (2,5-dioxopyrrolidin-1-yl)propanedioate; Diethyl N-succinimidyl malonate; N-Succinimidyl diethyl malonate; Succinimidyl diethyl malonate; 1-[(Diethoxycarbonyl)acetyl]pyrrolidine-2,5-dione; Diethyl (2,5-dioxo-1-pyrrolidinyl)malonate; Diethyl 2-(2,5-dioxo-1-pyrrolidinyl)malonate; Propanedioic acid, 1-(2,5-dioxo-1-pyrrolidinyl)-, diethyl ester
EINECS	Contact for details

Quality Control

Our Propanedioic Acid, (2,5-Dioxo-1-Pyrrolidinyl)-, Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical-grade intermediates. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.