Description

4-Hydroxy-Methyl-Benzoic Acid Mono tert-Butyl Ester is a key protected intermediate in organic synthesis, offering a versatile building block for complex molecule construction. Its value lies in the strategic protection of the carboxylic acid group, which allows for selective reactions on other functional sites, particularly the hydroxymethyl group. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, dyes, and liquid crystal materials.
• Peptide Chemistry: The tert-butyl ester group provides a base-labile protecting group for carboxylic acids in peptide synthesis.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	4-Hydroxy-Methyl-Benzoic Acid Mono tert-Butyl Ester
CAS No.	143726-85-6
Molecular Formula	C12H16O3
Molecular Weight	208.25 g/mol
Synonyms	4-(Hydroxymethyl)benzoic acid tert-butyl ester; 4-(Hydroxymethyl)benzoic acid 1,1-dimethylethyl ester; Benzoic acid, 4-(hydroxymethyl)-, 1,1-dimethylethyl ester; p-(Hydroxymethyl)benzoic acid tert-butyl ester; tert-Butyl 4-(hydroxymethyl)benzoate; 4-Carboxybenzyl alcohol tert-butyl ester; TBMB; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-Methyl-Benzoic Acid Mono tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.