Description

trans-3-Azido-1-Boc-4-Hydroxypyrrolidine CAS NO 143700-05-4 is a versatile and high-purity chemical building block featuring a protected amine (Boc) and a reactive azide functional group. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and biotechnology industries for applications such as click chemistry, peptide mimetics, and the construction of novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing pyrrolidine-based structures.
• Click Chemistry Reagent: The azide group enables efficient Huisgen 1,3-dipolar cycloaddition reactions with alkynes, facilitating rapid library synthesis for drug discovery.
• Peptidomimetic Synthesis: Used to introduce constrained, heterocyclic elements into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Probe Development: Serves as a precursor for creating chemical probes and ligands used in biochemical assays and diagnostic research.
• Agrochemical Research: Employed in the synthesis of novel compounds with potential herbicidal or insecticidal activity.
• Material Science: Can be utilized in the surface functionalization of polymers and nanoparticles via its reactive handles.

Basic Information

Product Name	trans-3-Azido-1-Boc-4-Hydroxypyrrolidine
CAS No.	143700-05-4
Molecular Formula	C9H16N4O3
Molecular Weight	228.25 g/mol
Synonyms	1-Boc-3-azido-4-hydroxypyrrolidine; tert-Butyl 3-azido-4-hydroxypyrrolidine-1-carboxylate; (3R,4R)-1-(tert-Butoxycarbonyl)-3-azido-4-hydroxypyrrolidine; (3S,4S)-1-(tert-Butoxycarbonyl)-3-azido-4-hydroxypyrrolidine; 1-N-Boc-3-azido-4-hydroxypyrrolidine; 3-Azido-1-Boc-4-hydroxypyrrolidine; Azido-Boc-hydroxypyrrolidine; Pyrrolidine, 3-azido-1-[(1,1-dimethylethoxy)carbonyl]-4-hydroxy-, (3R,4R)-rel-
EINECS	Contact for details

Quality Control

Our trans-3-Azido-1-Boc-4-Hydroxypyrrolidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.